Tomtom home 2.7.68/5/2023 ![]() This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.ĭata Availability: The RNAseq data is available in GEO, with the accession number GSE166681.įunding: Funding was provided by: Academy of Finland (MetaStem Center of Excellence funding 312439) to VH, Sigrid Juselius Foundation to VH, Novo Nordisk Foundation (NNF18OC0034406 and NNF19OC0057478) to VH, Jane and Aatos Erkko Foundation to VH, and Integrative Life Science Doctoral Program to NL. Received: FebruAccepted: OctoPublished: October 11, 2021Ĭopyright: © 2021 Kokki et al. Barsh, HudsonAlpha Institute for Biotechnology, UNITED STATES (2021) Metabolic gene regulation by Drosophila GATA transcription factor Grain. Collectively, our study provides evidence for the role of a metazoan GATA transcription factor in nutrient-responsive metabolic gene regulation in vivo.Ĭitation: Kokki K, Lamichane N, Nieminen AI, Ruhanen H, Morikka J, Robciuc M, et al. Consistently with these differential tissue-specific roles, Grain deficient larvae display delayed development on high sugar diet, while showing deregulated central carbon and lipid metabolism primarily on low sugar diet. On the other hand, grain displays strong constitutive expression in the anterior midgut, where it drives lipogenic gene expression also under low sugar conditions. grain expression is activated by sugar in Mondo-Mlx-dependent manner and it contributes to sugar-responsive gene expression in the fat body. De novo motif prediction uncovered a significant over-representation of GATA-like motifs on the promoters of sugar-activated genes in Drosophila larvae, which are regulated by Grain, the fly ortholog of GATA1/2/3 subfamily. Here we identify a role for Drosophila GATA TF Grain in metabolic gene regulation under both low and high sugar conditions. TFs that correspondingly control sugar responsive metabolic genes under conditions of low dietary sugar remain, however, poorly understood. In Drosophila, dietary sugars activate transcription factors (TFs), such as Mondo-Mlx, Sugarbabe and Cabut, which control metabolic gene expression to mediate physiological adaptation to high sugar diet. /theme_assets/9171351/1181f8f514e03c276d276ca3ecc72ad3819c0bed.Nutrient-dependent gene regulation critically contributes to homeostatic control of animal physiology in changing nutrient landscape. Note : The following navigation devices do not connect to HOME: GO 800/1000/2000 series, GO LIVE Top Gear edition, Via series, Start 20 series, Start 60, Blue&Me TomTom 2 LIVE, Sony XNV, TomTom Connect, GO 40, GO 50, GO 51, GO 60, GO 61, GO 400, GO 500, GO 600, GO 510, GO 610, Rider 410, Rider 400, Rider 40, GO 5000, GO 6000, GO 5100, GO 6100, Trucker 5000, Trucker 6000, START 40, START 50, START 60, Start 42, Start 52, Start 62, VIA 52, VIA 62, GO 520 Wi-Fi, GO 620 Wi-Fi, Rider 500, Rider 550, GO 5200 Wi-Fi, GO 6200 Wi-Fi, GO Basic,GO Classic, GO Essential, GO Premium, GO Premium X, GO Camper, GO Discover. TomTom HOME is installed on your computer.Īfter you have installed the software, click this link to see the steps for updating your device using TomTom Home: Updating the software on your navigation device (TomTom HOME) If you are not allowed to administer the computer, contact the admin for the computer. You are asked to agree to the terms of the software license agreement. To read the end user licence agreement, click the link. ![]() Double-click TomTomHOME2mac.dmg/TomTomHOME2mac-arm64.dmg.From the Finder menu at the top of the screen, click Go and choose Downloads.
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